The Genetics of Treatment-Resistant Depression: A Critical Review and Future Perspectives.

ABSTRACT: Background:One-third of depressed patients develop treatment-resistant depression with the related sequelae in terms of poor functionality and worse prognosis. Solid evidence suggests that genetic variants are potentially valid predictors of antidepressant efficacy and could be used to provide personalized treatments. Methods:The present review summarizes genetic findings of treatment-resistant depression including results from candidate gene studies and genome-wide association studies. The limitations of these approaches are discussed, and suggestions to improve the design of future studies are provided. Results:Most studies used the candidate gene approach, and few genes showed replicated associations with treatment-resistant depression and/or evidence obtained through complementary appr

SUBMITTER: Fabbri C 

PROVIDER: S-EPMC6368368 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature