Ontology highlight
ABSTRACT:
SUBMITTER: Ramakrishnan SK
PROVIDER: S-EPMC6368617 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Ramakrishnan Sadeesh K SK Zhang Huabing H Ma Xiaoya X Jung Inkyung I Schwartz Andrew J AJ Triner Daniel D Devenport Samantha N SN Das Nupur K NK Xue Xiang X Zeng Melody Y MY Hu Yinling Y Mortensen Richard M RM Greenson Joel K JK Cascalho Marilia M Wobus Christiane E CE Colacino Justin A JA Nunez Gabriel G Rui Liangyou L Shah Yatrik M YM
Nature communications 20190208 1
Microfold cells (M-cells) are specialized cells of the intestine that sample luminal microbiota and dietary antigens to educate the immune cells of the intestinal lymphoid follicles. The function of M-cells in systemic inflammatory responses are still unclear. Here we show that epithelial non-canonical NFkB signaling mediated by NFkB-inducing kinase (NIK) is highly active in intestinal lymphoid follicles, and is required for M-cell maintenance. Intestinal NIK signaling modulates M-cell different ...[more]