Unknown

Dataset Information

0

Intestinal non-canonical NF?B signaling shapes the local and systemic immune response.


ABSTRACT: Microfold cells (M-cells) are specialized cells of the intestine that sample luminal microbiota and dietary antigens to educate the immune cells of the intestinal lymphoid follicles. The function of M-cells in systemic inflammatory responses are still unclear. Here we show that epithelial non-canonical NFkB signaling mediated by NFkB-inducing kinase (NIK) is highly active in intestinal lymphoid follicles, and is required for M-cell maintenance. Intestinal NIK signaling modulates M-cell differentiation and elicits both local and systemic IL-17A and IgA production. Importantly, intestinal NIK signaling is active in mouse models of colitis and patients with inflammatory bowel diseases; meanwhile, constitutive NIK signaling increases the susceptibility to inflammatory injury by inducing ectopic M-cell differentiation and a chronic increase of IL-17A. Our work thus defines an important function of non-canonical NFkB and M-cells in immune homeostasis, inflammation and polymicrobial sepsis.

SUBMITTER: Ramakrishnan SK 

PROVIDER: S-EPMC6368617 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications


Microfold cells (M-cells) are specialized cells of the intestine that sample luminal microbiota and dietary antigens to educate the immune cells of the intestinal lymphoid follicles. The function of M-cells in systemic inflammatory responses are still unclear. Here we show that epithelial non-canonical NFkB signaling mediated by NFkB-inducing kinase (NIK) is highly active in intestinal lymphoid follicles, and is required for M-cell maintenance. Intestinal NIK signaling modulates M-cell different  ...[more]

Similar Datasets

| S-EPMC3193406 | biostudies-other
2020-01-11 | GSE142774 | GEO
| S-EPMC5725530 | biostudies-literature
| S-EPMC4425414 | biostudies-literature
| S-EPMC3857575 | biostudies-literature
| S-SCDT-10_1038-S44318-024-00182-6 | biostudies-other
| S-EPMC7111210 | biostudies-literature
2020-01-07 | GSE141546 | GEO
| S-EPMC4563092 | biostudies-literature
2016-02-18 | E-GEOD-64232 | biostudies-arrayexpress