Ontology highlight
ABSTRACT:
SUBMITTER: Allen SD
PROVIDER: S-EPMC6368678 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Allen Sean D SD Liu Yu-Gang YG Kim Taehyeung T Bobbala Sharan S Yi Sijia S Zhang Xiaohan X Choi Jaehyuk J Scott Evan A EA
Biomaterials science 20190101 2
In this work, the hydrophobic small molecule NF-κB inhibitor celastrol was loaded into poly(ethylene glycol)-b-poly(propylene sulfide) (PEG-b-PPS) micelles. PEG-b-PPS micelles demonstrated high loading efficiency, low polydispersity, and no morphological changes upon loading with celastrol. Encapsulation of celastrol within these nanocarriers significantly reduced cytotoxicity compared to free celastrol, while simultaneously expanding the lower concentration range for effective inhibition of NF- ...[more]