DNA methylome profiling of all-cause mortality in comparison with age-associated methylation patterns.
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ABSTRACT:
SUBMITTER: Lund JB
PROVIDER: S-EPMC6368749 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
DNA methylome profiling of all-cause mortality in comparison with age-associated methylation patterns.
Lund Jesper Beltoft JB Li Shuxia S Baumbach Jan J Svane Anne Marie AM Hjelmborg Jacob J Christiansen Lene L Christensen Kaare K Redmond Paul P Marioni Riccardo E RE Deary Ian J IJ Tan Qihua Q
Clinical epigenetics 20190208 1
<h4>Background</h4>Multiple epigenome-wide association studies have been performed to identify DNA methylation patterns regulated by aging or correlated with risk of death. However, the inter-relatedness of the epigenetic basis of aging and mortality has not been well investigated.<h4>Methods</h4>Using genome-wide DNA methylation data from the Lothian Birth Cohorts, we conducted a genome-wide association analysis of all-cause mortality and compared this with age-associated methylation patterns r ...[more]
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