Ontology highlight
ABSTRACT:
SUBMITTER: Pogrebniak KL
PROVIDER: S-EPMC6368975 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Pogrebniak Katherine L KL Curtis Christina C
Trends in genetics : TIG 20180611 8
High-throughput sequencing can be used to measure changes in tumor composition across space and time. Specifically, comparisons of pre- and post-treatment samples can reveal the underlying clonal dynamics and resistance mechanisms. Here, we discuss evidence for distinct modes of tumor evolution and their implications for therapeutic strategies. In addition, we consider the utility of spatial tissue sampling schemes, single-cell analysis, and circulating tumor DNA to track tumor evolution and the ...[more]