Ontology highlight
ABSTRACT:
SUBMITTER: Shen C
PROVIDER: S-EPMC6369754 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Shen Chen C Lu Alvin A Xie Wen Jun WJ Ruan Jianbin J Negro Roberto R Egelman Edward H EH Fu Tian-Min TM Wu Hao H
Proceedings of the National Academy of Sciences of the United States of America 20190123 6
Inflammasomes are large protein complexes that trigger host defense in cells by activating inflammatory caspases for cytokine maturation and pyroptosis. NLRP6 is a sensor protein in the nucleotide-binding domain (NBD) and leucine-rich repeat (LRR)-containing (NLR) inflammasome family that has been shown to play multiple roles in regulating inflammation and host defenses. Despite the significance of the NLRP6 inflammasome, little is known about the molecular mechanism behind its assembly and acti ...[more]