Ontology highlight
ABSTRACT:
SUBMITTER: Poulton JM
PROVIDER: S-EPMC6369769 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Poulton Jenny M JM Ten Wolde Pieter Rein PR Ouldridge Thomas E TE
Proceedings of the National Academy of Sciences of the United States of America 20190118 6
Living systems produce "persistent" copies of information-carrying polymers, in which template and copy sequences remain correlated after physically decoupling. We identify a general measure of the thermodynamic efficiency with which these nonequilibrium states are created and analyze the accuracy and efficiency of a family of dynamical models that produce persistent copies. For the weakest chemical driving, when polymer growth occurs in equilibrium, both the copy accuracy and, more surprisingly ...[more]