Engineering bioorthogonal protein-polymer hybrid hydrogel as a functional protein immobilization platform.
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ABSTRACT:
SUBMITTER: Lim S
PROVIDER: S-EPMC6370476 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
Engineering bioorthogonal protein-polymer hybrid hydrogel as a functional protein immobilization platform.
Lim Samuel S Jung Gi Ahn GA Muckom Riya J RJ Glover Dominic J DJ Clark Douglas S DS
Chemical communications (Cambridge, England) 20190101 6
We demonstrate the synthesis of protein-polymer hybrid hydrogel that can be used as a platform for immobilizing functional proteins. Orthogonal chemistry was employed for cross-linking the hybrid network and conjugating proteins to the gel backbone, allowing for the convenient, one-pot formation of a functionalized hydrogel. The resulting hydrogel had tunable mechanical properties, was stable in solution, and biocompatible. ...[more]
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