Dataset Information

Evaluation of confound regression strategies for the mitigation of micromovement artifact in studies of dynamic resting-state functional connectivity and multilayer network modularity.

ABSTRACT: Dynamic functional connectivity reflects the spatiotemporal organization of spontaneous brain activity in health and disease. Dynamic functional connectivity may be susceptible to artifacts induced by participant motion. This report provides a systematic evaluation of 12 commonly used participant-level confound regression strategies designed to mitigate the effects of micromovements in a sample of 393 youths (ages 8-22 years). Each strategy was evaluated according to a number of benchmarks, including (a) the residual association between participant motion and edge dispersion, (b) distance-dependent effects of motion on edge dispersion, (c) the degree to which functional subnetworks could be identified by multilayer modularity maximization, and (d) measures of module reconfiguration, including node flexibility and node promiscuity. Results indicate variability in the effectiveness of the evaluated pipelines across benchmarks. Methods that included global signal regression were the most consistently effective de-noising strategies.

SUBMITTER: Lydon-Staley DM

PROVIDER: S-EPMC6370491 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Evaluation of confound regression strategies for the mitigation of micromovement artifact in studies of dynamic resting-state functional connectivity and multilayer network modularity.

Lydon-Staley David M DM Ciric Rastko R Satterthwaite Theodore D TD Bassett Danielle S DS

Network neuroscience (Cambridge, Mass.) 20190201 2

Dynamic functional connectivity reflects the spatiotemporal organization of spontaneous brain activity in health and disease. Dynamic functional connectivity may be susceptible to artifacts induced by participant motion. This report provides a systematic evaluation of 12 commonly used participant-level confound regression strategies designed to mitigate the effects of micromovements in a sample of 393 youths (ages 8-22 years). Each strategy was evaluated according to a number of benchmarks, incl ...[more]

PMID: 30793090

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Project description:Global signal regression (GSR) is one of the most debated preprocessing strategies for resting-state functional MRI. GSR effectively removes global artifacts driven by motion and respiration, but also discards globally distributed neural information and introduces negative correlations between certain brain regions. The vast majority of previous studies have focused on the effectiveness of GSR in removing imaging artifacts, as well as its potential biases. Given the growing interest in functional connectivity fingerprinting, here we considered the utilitarian question of whether GSR strengthens or weakens associations between resting-state functional connectivity (RSFC) and multiple behavioral measures across cognition, personality and emotion. By applying the variance component model to the Brain Genomics Superstruct Project (GSP), we found that behavioral variance explained by whole-brain RSFC increased by an average of 47% across 23 behavioral measures after GSR. In the Human Connectome Project (HCP), we found that behavioral variance explained by whole-brain RSFC increased by an average of 40% across 58 behavioral measures, when GSR was applied after ICA-FIX de-noising. To ensure generalizability, we repeated our analyses using kernel regression. GSR improved behavioral prediction accuracies by an average of 64% and 12% in the GSP and HCP datasets respectively. Importantly, the results were consistent across methods. A behavioral measure with greater RSFC-explained variance (using the variance component model) also exhibited greater prediction accuracy (using kernel regression). A behavioral measure with greater improvement in behavioral variance explained after GSR (using the variance component model) also enjoyed greater improvement in prediction accuracy after GSR (using kernel regression). Furthermore, GSR appeared to benefit task performance measures more than self-reported measures. Since GSR was more effective at removing motion-related and respiratory-related artifacts, GSR-related increases in variance explained and prediction accuracies were unlikely the result of motion-related or respiratory-related artifacts. However, it is worth emphasizing that the current study focused on whole-brain RSFC, so it remains unclear whether GSR improves RSFC-behavioral associations for specific connections or networks. Overall, our results suggest that at least in the case for young healthy adults, GSR strengthens the associations between RSFC and most (although not all) behavioral measures. Code for the variance component model and ridge regression can be found here: https://github.com/ThomasYeoLab/CBIG/tree/master/stable_projects/preprocessing/Li2019_GSR.

Dataset Information

Evaluation of confound regression strategies for the mitigation of micromovement artifact in studies of dynamic resting-state functional connectivity and multilayer network modularity.

Publications

Evaluation of confound regression strategies for the mitigation of micromovement artifact in studies of dynamic resting-state functional connectivity and multilayer network modularity.

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