Evaluating the Accuracy of Imputation Methods in a Five-Way Admixed Population.
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ABSTRACT:
SUBMITTER: Schurz H
PROVIDER: S-EPMC6370942 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Evaluating the Accuracy of Imputation Methods in a Five-Way Admixed Population.
Schurz Haiko H Müller Stephanie J SJ van Helden Paul David PD Tromp Gerard G Hoal Eileen G EG Kinnear Craig J CJ Möller Marlo M
Frontiers in genetics 20190205
Genotype imputation is a powerful tool for increasing statistical power in an association analysis. Meta-analysis of multiple study datasets also requires a substantial overlap of SNPs for a successful association analysis, which can be achieved by imputation. Quality of imputed datasets is largely dependent on the software used, as well as the reference populations chosen. The accuracy of imputation of available reference populations has not been tested for the five-way admixed South African Co ...[more]
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