Evidence Based Review of Fitness-to-Drive and Return-to-Driving Following Traumatic Brain Injury.
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ABSTRACT:
SUBMITTER: Palubiski L
PROVIDER: S-EPMC6371138 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
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Evidence Based Review of Fitness-to-Drive and Return-to-Driving Following Traumatic Brain Injury.
Palubiski Lisa L Crizzle Alexander M AM
Geriatrics (Basel, Switzerland) 20160707 3
The purpose of this study was to conduct an evidence-based review to determine predictors of fitness to drive and return to driving in persons with traumatic brain injury (TBI). Relevant databases (MEDLINE/PubMed, CINAHL, Cochrane Library, and SCOPUS) were searched for primary articles published before June 2016 using MeSH search terms. Using the American Academy of Neurology's classification criteria, 24 articles were included after reviewing 1998 articles. Studies were rated by class (I⁻IV), w ...[more]
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Project description:While generalized cerebral atrophy and neurodegenerative change following traumatic brain injury (TBI) is well recognized in adults, it remains comparatively understudied in the pediatric population, suggesting that research should address the potential for neurodegenerative change in children and youth following TBI. This focused review examines original research findings documenting evidence for neurodegenerative change following TBI of all severities in children and youth. Our relevant inclusion and exclusion criteria identified a total of 16 articles for review. Taken together, the studies reviewed suggest there is evidence for long-term neurodegenerative change following TBI in children and youth. In particular both cross-sectional and longitudinal studies revealed volume loss in selected brain regions including the hippocampus, amygdala, globus pallidus, thalamus, periventricular white matter, cerebellum, and brain stem as well as overall decreased whole brain volume and increased CSF and ventricular space. Diffusion Tensor Imaging (DTI) studies also report evidence for decreased cellular integrity, particularly in the corpus callosum. Sensitivity of the hippocampus and deep limbic structures in pediatric populations are similar to findings in the adult literature and we consider the data supporting these changes as well as the need to investigate the possibility of neurodegenerative onset in childhood associated with mild traumatic brain injury (mTBI).
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