Ontology highlight
ABSTRACT:
SUBMITTER: Ngow YS
PROVIDER: S-EPMC6371211 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Ngow Yeen Shian YS Rajan Sreekanth S Ye Hong H Yoon Ho Sup HS
Protein science : a publication of the Protein Society 20181220 3
Vaccinia-related kinase 1 (VRK1), a serine/threonine mitotic kinase, is widely over-expressed in dividing cells and regarded as a cancer drug target primarily due to its function as an early response gene in cell proliferation. However, the mechanism of VRK1 phosphorylation and substrate activation is not well understood. More importantly even the molecular basis of VRK1 interaction with its cofactor, adenosine triphosphate (ATP), is unavailable to-date. As designing specific inhibitors remains ...[more]