Social affiliation predicts mitochondrial DNA copy number in female rhesus macaques.
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ABSTRACT:
SUBMITTER: Debray R
PROVIDER: S-EPMC6371908 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
Social affiliation predicts mitochondrial DNA copy number in female rhesus macaques.
Debray Reena R Snyder-Mackler Noah N Kohn Jordan N JN Wilson Mark E ME Barreiro Luis B LB Tung Jenny J
Biology letters 20190101 1
In many social mammals, social adversity predicts compromised health and reduced fitness. These effects are thought to be driven in part by chronic social stress, but their molecular underpinnings are not well understood. Recent work suggests that chronic stress can affect mitochondrial copy number, heteroplasmy rates and function. Here, we tested the first two possibilities for the first time in non-human primates. We manipulated dominance rank in captive female rhesus macaques ( n = 45), where ...[more]
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