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Suppression of scratching-induced pleasurable sensation by compression nerve blocking and its association with itch relief.

ABSTRACT: Itch can be suppressed by scratching. At the same time, scratching evokes a pleasurable sensation. In the present study, we investigated the peripheral mechanism of scratching-induced pleasurability and its association with itch relief using compression nerve block. We found that myelinated nerve fibers (A?-fibers and possibly A?-fibers), are involved in transmission of scratching-induced pleasurability. We observed that itch relief effect was the same regardless of whether the pleasurable sensation was evoked by scratching an itch, indicating that pleasure is not a necessary component to induce itch relief. This is the first study to investigate the peripheral mechanism of scratching-induced pleasurability and itch relief.

SUBMITTER: Mochizuki H

PROVIDER: S-EPMC6372058 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Suppression of scratching-induced pleasurable sensation by compression nerve blocking and its association with itch relief.

Mochizuki Hideki H Shevchenko Alina A Nattkemper Leigh A LA Valdes-Rodriguez Rodrigo R Yosipovitch Gil G

Itch (Philadelphia, Pa.) 20170901 2

Itch can be suppressed by scratching. At the same time, scratching evokes a pleasurable sensation. In the present study, we investigated the peripheral mechanism of scratching-induced pleasurability and its association with itch relief using compression nerve block. We found that myelinated nerve fibers (Aβ-fibers and possibly Aδ-fibers), are involved in transmission of scratching-induced pleasurability. We observed that itch relief effect was the same regardless of whether the pleasurable sensa ...[more]

PMID: 30828642

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