Ontology highlight
ABSTRACT:
SUBMITTER: Meneguetti GP
PROVIDER: S-EPMC6372183 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Meneguetti Giovanna Pastore GP Santos João Henrique Picado Madalena JHPM Obreque Karin Mariana Torres KMT Barbosa Christiano Marcello Vaz CMV Monteiro Gisele G Farsky Sandra Helena Poliselli SHP Marim de Oliveira Adriano A Angeli Claudia Blanes CB Palmisano Giuseppe G Ventura Sónia Patrícia Marques SPM Pessoa-Junior Adalberto A de Oliveira Rangel-Yagui Carlota C
PloS one 20190212 2
L-asparaginase (ASNase) from Escherichia coli is currently used in some countries in its PEGylated form (ONCASPAR, pegaspargase) to treat acute lymphoblastic leukemia (ALL). PEGylation refers to the covalent attachment of poly(ethylene) glycol to the protein drug and it not only reduces the immune system activation but also decreases degradation by plasmatic proteases. However, pegaspargase is randomly PEGylated and, consequently, with a high degree of polydispersity in its final formulation. In ...[more]