Role of Anti-PD-1 Antibodies in Advanced Melanoma: The Era of Immunotherapy.
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ABSTRACT:
SUBMITTER: Sahni S
PROVIDER: S-EPMC6372252 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
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Role of Anti-PD-1 Antibodies in Advanced Melanoma: The Era of Immunotherapy.
Sahni Sakshi S Valecha Gautam G Sahni Ankit A
Cureus 20181207 12
Advanced melanoma is an aggressive skin cancer characterized by poor survival rates and response to cytotoxic chemotherapy. Immune checkpoint inhibitors are novel agents capable of utilizing one's own immune system to bring about the tumor destruction. Nivolumab and pembrolizumab are fully humanized anti-PD-1 monoclonal antibodies that have shown significant anti-tumor activity in a variety of cancers including melanoma and have significantly improved the survival outcomes in patients with advan ...[more]
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