The Ebola Viral Protein 35 N-Terminus Is a Parallel Tetramer.

ABSTRACT: Members of Mononegavirales, the order that includes nonsegmented negative sense RNA viruses (NNSVs), encode a small number of multifunctional proteins. In members of the Filoviridae family, virus protein 35 (VP35) facilitates immune evasion and functions as an obligatory cofactor for viral RNA synthesis. VP35 functions in a manner orthologous to that of phosphoproteins from other NNSVs. Although the critical roles of Ebola viral VP35 (eVP35) in immune evasion and RNA synthesis are well-appreciated, a complete understanding of its organization and its role in carrying out its many functions has yet to be fully realized. In particular, we currently lack information about the role of the oligomerization domain within eVP35. To address this limitation, we report here an investigation of the ol

SUBMITTER: Chanthamontri CK 

PROVIDER: S-EPMC6372349 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature