Ontology highlight
ABSTRACT:
SUBMITTER: Djurisic M
PROVIDER: S-EPMC6372352 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Djurisic Maja M Brott Barbara K BK Saw Nay L NL Shamloo Mehrdad M Shatz Carla J CJ
Molecular psychiatry 20180418 8
The threshold for Hebbian synaptic plasticity in the CNS is modulated by prior synaptic activity. At adult CA3-CA1 synapses, endocannabinoids play a role in this process, but how activity engages and maintains this retrograde signaling system is not well understood. Here we show that conditional deletion of Paired Immunoglobulin-like receptor B (PirB) from pyramidal neurons in adult mouse hippocampus results in deficient LTD at CA3-CA1 synapses over a range of stimulation frequencies, accompanie ...[more]