Ontology highlight
ABSTRACT:
SUBMITTER: Kostyushev D
PROVIDER: S-EPMC6372644 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Scientific reports 20190212 1
Chronic hepatitis B is a severe liver disease caused by hepatitis B virus (HBV) infection. Covalently closed circular DNA (cccDNA), a super-spiralized, double-stranded form of the HBV genome, is the major determinant of viral persistence. CRISPR/Cas9 nucleases have been recently shown to introduce double-stranded DNA breaks into HBV cccDNA. The inflicted damage results predominantly in erroneous repair of cccDNA by non-homologous end-joining (NHEJ). NHEJ has been suggested to enhance anti-HBV ac ...[more]