Novel Treatment Opportunities Against Cognitive Impairment in Parkinson's Disease with an Emphasis on Diabetes-Related Pathways.
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ABSTRACT:
SUBMITTER: Green H
PROVIDER: S-EPMC6373401 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
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Novel Treatment Opportunities Against Cognitive Impairment in Parkinson's Disease with an Emphasis on Diabetes-Related Pathways.
Green Holly H Tsitsi Panagiota P Markaki Ioanna I Aarsland Dag D Svenningsson Per P
CNS drugs 20190201 2
Cognitive impairment is highly prevalent in patients with Parkinson's disease (PD) and causes adverse health outcomes. Novel procognitive therapies are needed to address this unmet need. It is now established that there is an increased risk of dementia in patients with type 2 diabetes mellitus (T2DM) and, moreover, T2DM and PD may have common underlying biological mechanisms. As such, T2DM medications are emerging as potential therapies in the context of PD dementia (PDD). In this review, we pro ...[more]
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