Unknown

Dataset Information

0

Cerebellar Functional Connectivity in Term- and Very Preterm-Born Infants.


ABSTRACT: Cortical resting state networks have been consistently identified in infants using resting state-functional connectivity magnetic resonance imaging (rs-fMRI). Comparable studies in adults have demonstrated cerebellar components of well-established cerebral networks. However, there has been limited investigation of early cerebellar functional connectivity. We acquired non-sedated rs-fMRI data in the first week of life in 57 healthy, term-born infants and at term-equivalent postmenstrual age in 20 very preterm infants (mean birth gestational age 27 ± 2 weeks) without significant cerebral or cerebellar injury. Seed correlation analyses were performed using regions of interests spanning the cortical and subcortical gray matter and cerebellum. Parallel analyses were performed using rs-fMRI data acquired in 100 healthy adults. Our results demonstrate that cortico-cerebellar functional connectivity is well-established by term. Intra- and cortico-cerebellar functional connectivity were largely similar in infants and adults. However, infants showed more functional connectivity structure within the cerebellum, including stronger homotopic correlations and more robust anterior-posterior anticorrelations. Prematurity was associated with reduced correlation magnitudes, but no alterations in intra- and cortico-cerebellar functional connectivity topography. These results add to the growing evidence that the cerebellum plays an important role in shaping early brain development during infancy.

SUBMITTER: Herzmann CS 

PROVIDER: S-EPMC6373668 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Cerebellar Functional Connectivity in Term- and Very Preterm-Born Infants.

Herzmann Charlotte S CS   Snyder Abraham Z AZ   Kenley Jeanette K JK   Rogers Cynthia E CE   Shimony Joshua S JS   Smyser Christopher D CD  

Cerebral cortex (New York, N.Y. : 1991) 20190301 3


Cortical resting state networks have been consistently identified in infants using resting state-functional connectivity magnetic resonance imaging (rs-fMRI). Comparable studies in adults have demonstrated cerebellar components of well-established cerebral networks. However, there has been limited investigation of early cerebellar functional connectivity. We acquired non-sedated rs-fMRI data in the first week of life in 57 healthy, term-born infants and at term-equivalent postmenstrual age in 20  ...[more]

Similar Datasets

| S-EPMC6765421 | biostudies-literature
| S-EPMC7859832 | biostudies-literature
| S-EPMC6258200 | biostudies-literature
| S-EPMC6214877 | biostudies-literature
| S-EPMC8179512 | biostudies-literature
| S-EPMC10952560 | biostudies-literature
| S-EPMC5080670 | biostudies-literature
| S-EPMC10527115 | biostudies-literature
| S-EPMC5740078 | biostudies-literature
| S-EPMC10709020 | biostudies-literature