Ontology highlight
ABSTRACT:
SUBMITTER: Hung S
PROVIDER: S-EPMC6374075 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Hung Stevephen S Saiakhova Alina A Faber Zachary J ZJ Bartels Cynthia F CF Neu Devin D Bayles Ian I Ojo Evelyn E Hong Ellen S ES Pontius W Dean WD Morton Andrew R AR Liu Ruifu R Kalady Matthew F MF Wald David N DN Markowitz Sanford S Scacheri Peter C PC
eLife 20190213
Commonly-mutated genes have been found for many cancers, but less is known about mutations in cis-regulatory elements. We leverage gains in tumor-specific enhancer activity, coupled with allele-biased mutation detection from H3K27ac ChIP-seq data, to pinpoint potential enhancer-activating mutations in colorectal cancer (CRC). Analysis of a genetically-diverse cohort of CRC specimens revealed that microsatellite instable (MSI) samples have a high indel rate within active enhancers. Enhancers with ...[more]