Biologic Markers of Antibiotic-Refractory Lyme Arthritis in Human: A Systematic Review.

ABSTRACT:

Introduction

Lyme disease-also known as Lyme borreliosis (LB)-is the most common vector-borne disease in North America and Europe. It may result in substantial morbidity, primarily from persistent Lyme arthritis (LA) that-although treatable-can develop into antibiotic-refractory LA (A-RLA). The aim of this study is to systematically review and evaluate a range of biomarkers for their potential predictive value in the development of A-RLA.

Methods

We conducted a systematic review of studies examining biomarkers among patients with A-RLA from MEDLINE via OVID, EMBASE and Web of Science databases and identified a total of 26 studies for qualitative analysis.

Results

All studies were of patient populations from the USA, with the exception of one from Europe. We identified

SUBMITTER: Badawi A 

PROVIDER: S-EPMC6374232 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature