Predicting Fracture Risk in Younger Postmenopausal Women: Comparison of the Garvan and FRAX Risk Calculators in the Women's Health Initiative Study.

ABSTRACT:

Background

Guidelines recommend fracture risk assessment in postmenopausal women aged 50-64, but the optimal method is unknown.

Objectives

To compare discrimination and calibration of the Fracture Risk Assessment Tool (FRAX) and Garvan fracture risk calculator for predicting fractures in postmenopausal women aged 50-64 at baseline.

Design

Prospective observational study.

Participants

Sixty-three thousand seven hundred twenty-three postmenopausal women aged 50-64 years participating in the Women's Health Initiative Observational Study and Clinical Trials.

Main measures

Incident hip fractures and major osteoporotic fractures (MOF) during 10-year follow-up. Calculated FRAX- and Garvan-predicted hip fracture and MOF fracture probabilities.

Key results

SUBMITTER: Crandall CJ 

PROVIDER: S-EPMC6374270 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature