Kynurenine 3-monooxygenase is a critical regulator of renal ischemia-reperfusion injury.
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ABSTRACT:
SUBMITTER: Zheng X
PROVIDER: S-EPMC6374422 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
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Kynurenine 3-monooxygenase is a critical regulator of renal ischemia-reperfusion injury.
Zheng Xiaozhong X Zhang Ailiang A Binnie Margaret M McGuire Kris K Webster Scott P SP Hughes Jeremy J Howie Sarah E M SEM Mole Damian J DJ
Experimental & molecular medicine 20190213 2
Acute kidney injury (AKI) following ischemia-reperfusion injury (IRI) has a high mortality and lacks specific therapies. Here, we report that mice lacking kynurenine 3-monooxygenase (KMO) activity (Kmo<sup>null</sup> mice) are protected against AKI after renal IRI. We show that KMO is highly expressed in the kidney and exerts major metabolic control over the biologically active kynurenine metabolites 3-hydroxykynurenine, kynurenic acid, and downstream metabolites. In experimental AKI induced by ...[more]
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