Basic Units of Inter-Individual Variation in Resting State Connectomes.

ABSTRACT: Resting state functional connectomes are massive and complex. It is an open question, however, whether connectomes differ across individuals in a correspondingly massive number of ways, or whether most differences take a small number of characteristic forms. We systematically investigated this question and found clear evidence of low-rank structure in which a modest number of connectomic components, around 50-150, account for a sizable portion of inter-individual connectomic variation. This number was convergently arrived at with multiple methods including estimation of intrinsic dimensionality and assessment of reconstruction of out-of-sample data. In addition, we show that these connectomic components enable prediction of a broad array of neurocognitive and clinical symptom variables at

SUBMITTER: Sripada C 

PROVIDER: S-EPMC6374507 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature