Ontology highlight
ABSTRACT:
SUBMITTER: Kim MA
PROVIDER: S-EPMC6374519 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Molecular therapy. Methods & clinical development 20190111
Targeting specific cell types in the mammalian inner ear is important for treating genetic hearing loss due to the different cell type-specific functions. Adeno-associated virus (AAV) is an efficient <i>in vivo</i> gene transfer vector, and it has demonstrated promise for treating genetic hearing loss. Although more than 100 AAV serotypes have been identified, few studies have investigated whether AAV can be distributed to specific inner ear cell types. Here we screened three EGFP-AAV reporter c ...[more]