Retinal-input-induced epigenetic dynamics in the developing mouse dorsal lateral geniculate nucleus.

ABSTRACT: DNA methylation plays important roles in the regulation of nervous system development and in cellular responses to environmental stimuli such as light-derived signals. Despite great efforts in understanding the maturation and refinement of visual circuits, we lack a clear understanding of how changes in DNA methylation correlate with visual activity in the developing subcortical visual system, such as in the dorsal lateral geniculate nucleus (dLGN), the main retino-recipient region in the dorsal thalamus. Here, we explored epigenetic dynamics underlying dLGN development at ages before and after eye opening in wild-type mice and mutant mice in which retinal ganglion cells fail to form. We observed that development-related epigenetic changes tend to co-localize together on functional genomic

SUBMITTER: He J 

PROVIDER: S-EPMC6374911 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature