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The Lag Structure of Intrinsic Activity is Focally Altered in High Functioning Adults with Autism.

ABSTRACT: The behaviors that define autism spectrum disorders (ASDs) have been hypothesized to result from disordered communication within brain networks. Several groups have investigated this question using resting-state functional magnetic resonance imaging (RS-fMRI). However, the published findings to date have been inconsistent across laboratories. Prior RS-fMRI studies of ASD have employed conventional analysis techniques based on the assumption that intrinsic brain activity is exactly synchronous over widely separated parts of the brain. By relaxing the assumption of synchronicity and focusing, instead, on lags between time series, we have recently demonstrated highly reproducible patterns of temporally lagged activity in normal human adults. We refer to this analysis technique as resting-state lag analysis (RS-LA). Here, we report RS-LA as well as conventional analyses of RS-fMRI in adults with ASD and demographically matched controls. RS-LA analyses demonstrated significant group differences in rs-fMRI lag structure in frontopolar cortex, occipital cortex, and putamen. Moreover, the degree of abnormality in individuals was highly correlated with behavioral measures relevant to the diagnosis of ASD. In this sample, no significant group differences were observed using conventional RS-fMRI analysis techniques. Our results suggest that altered propagation of intrinsic activity may contribute to abnormal brain function in ASD.

SUBMITTER: Mitra A

PROVIDER: S-EPMC6375249 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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The Lag Structure of Intrinsic Activity is Focally Altered in High Functioning Adults with Autism.

Mitra Anish A Snyder Abraham Z AZ Constantino John N JN Raichle Marcus E ME

Cerebral cortex (New York, N.Y. : 1991) 20170201 2

The behaviors that define autism spectrum disorders (ASDs) have been hypothesized to result from disordered communication within brain networks. Several groups have investigated this question using resting-state functional magnetic resonance imaging (RS-fMRI). However, the published findings to date have been inconsistent across laboratories. Prior RS-fMRI studies of ASD have employed conventional analysis techniques based on the assumption that intrinsic brain activity is exactly synchronous ov ...[more]

PMID: 26656726

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Project description:Background:Sex differences in autistic symptomatology are believed to contribute to the mis- and missed diagnosis of many girls and women with an autism spectrum condition (ASC). Whilst recent years have seen the emergence of clinical and empirical reports delineating the profile of young autistic girls, recognition of sex differences in symptomatology in adulthood is far more limited. Methods:We chose here to focus on symptomatology as reported using a screening instrument, the Ritvo Autism Asperger Diagnostic Scale-Revised (RAADS-R). In a meta-analysis, we pooled and analysed RAADS-R data from a number of experimental groups. Analysis of variance (ANOVA) searched for the presence of main effects of Sex and Diagnosis and for interactions between these factors in our sample of autistic and non-autistic adults. Results:In social relatedness and circumscribed interests, main effects of Diagnosis revealed that as expected, autistic adults reported significantly greater lifetime prevalence of symptoms in these domains; an effect of Sex, in circumscribed interests, also suggested that males generally reported more prevalent symptoms than females. An interaction of Sex and Diagnosis in language symptomatology revealed that a normative sex difference in language difficulties was attenuated in autism. An interaction of Sex and Diagnosis in the sensorimotor domain revealed the opposite picture: a lack of sex differences between typically developing men and women and a greater prevalence of sensorimotor symptoms in autistic women than autistic men. Conclusions:We discuss the literature on childhood sex differences in relation to those which emerged in our adult sample. Where childhood sex differences fail to persist in adulthood, several interpretations exist, and we discuss, for example, an inherent sampling bias that may mean that only autistic women most similar to the male presentation are diagnosed. The finding that sensorimotor symptomatology is more highly reported by autistic women is a finding requiring objective confirmation, given its potential importance in diagnosis.

Dataset Information

The Lag Structure of Intrinsic Activity is Focally Altered in High Functioning Adults with Autism.

Publications

The Lag Structure of Intrinsic Activity is Focally Altered in High Functioning Adults with Autism.

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