Ontology highlight
ABSTRACT:
SUBMITTER: Bresnick AR
PROVIDER: S-EPMC6375709 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Bresnick Anne R AR Backer Jonathan M JM
Endocrinology 20190301 3
The phosphoinositide 3-kinase (PI3K) family includes eight distinct catalytic subunits and seven regulatory subunits. Only two PI3Ks are directly regulated downstream from G protein-coupled receptors (GPCRs): the class I enzymes PI3Kβ and PI3Kγ. Both enzymes produce phosphatidylinositol 3,4,5-trisposphate in vivo and are regulated by both heterotrimeric G proteins and small GTPases from the Ras or Rho families. However, PI3Kβ is also regulated by direct interactions with receptor tyrosine kinase ...[more]