IL18 Gene Polymorphism Influences Age of Onset of DM1 in African Ancestry Brazilians.
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ABSTRACT:
SUBMITTER: Boechat-Fernandes A
PROVIDER: S-EPMC6375717 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
<i>IL18</i> Gene Polymorphism Influences Age of Onset of DM1 in African Ancestry Brazilians.
Boëchat-Fernandes Alejandro A Réa Rosângela Roginski RR Romanzini Nicole Balster NB Gomes Marilia Brito MB Furtado-Alle Lupe L Souza Ricardo L R RLR
Journal of pediatric genetics 20190130 1
The aim of this study was to investigate the relationship of two single nucleotide polymorphisms (SNPs) in the interleukin-18 ( <i>IL18</i> ) gene (rs187238, g.-137G > C; rs1946518, g.-607C > A) and one SNP of the <i>IL12B</i> gene (rs3212227 g.*159A > C, 3'UTR) with the age of onset for type 1 <i>diabetes mellitus</i> (DM1). A total of 1,101 patients with DM1 enrolled in 13 centers from different regions of Brazil were genotyped with TaqMan assay and classified according to the ancestry. Our re ...[more]
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