Real-time imaging of senescence in tumors with DNA damage.
Ontology highlight
ABSTRACT: Detection of cellular senescence is important not only in the study of senescence in various biological systems, but also in various practical applications such as image-guided surgical removal of senescent cells, as well as the monitoring of drug-responsiveness during cancer therapies. Due to the lack of suitable imaging probes for senescence detection, particularly in living subjects, we have developed an activatable near-infrared (NIR) molecular probe with far-red excitation, NIR emission, and high "turn-on" ratio upon senescence-associated β-galactosidase (SABG) activation. We present here the first successful demonstration of NIR imaging of DNA damage-induced senescence both in vitro and in human tumor xenograft models.
SUBMITTER: Wang Y
PROVIDER: S-EPMC6375927 | biostudies-literature |
REPOSITORIES: biostudies-literature
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