Ontology highlight
ABSTRACT:
SUBMITTER: Ierich JCM
PROVIDER: S-EPMC6376134 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Ierich Jéssica Cristiane Magalhães JCM Brum Doralina Guimarães DG Moraes Ariana de Souza AS Higa Akemi Martins AM Garcia Pâmela Soto PS Miyazaki Celina Massumi CM Ferreira Marystela M Peroni Luís Antonio LA Oliveira Guedmiller Souza de GS Franca Eduardo de Faria EF Freitas Luiz Carlos Gomide LCG Leite Fabio Lima FL
Scientific reports 20190214 1
Antigen-antibody interaction is crucial in autoimmune disease pathogenesis, as multiple sclerosis and neuromyelitis optica. Given that, autoantibodies are essential biomolecules, of which the myelin oligodendrocyte glycoprotein (MOG) can figure as a target. Here we combined Molecular Dynamics (MD), Steered Molecular Dynamics (SMD), and Atomic Force Microscope (AFM) to detail MOG recognition by its specific antibody. The complex model consisted of the MOG external domain interacting with an exper ...[more]