Dataset Information

Autoantibody detection is not recommended for chronic pancreatitis: a cross-sectional Study of 557 patients.

ABSTRACT:

Background

Autoimmune factor was regarded as one of the risk factors in the pathogenesis of chronic pancreatitis (CP), especially for autoimmune pancreatitis (AIP). However, whether autoimmune factor plays a role in non-AIP CP or not was unknown.

Methods

Hospitalized patients with non-AIP CP from January 2010 to October 2016 were detected for 22 autoantibodies at the time of hospital admission. Autoantibodies with frequency?>?0.5% were enrolled to calculate the frequency in historial healthy controls through literature search in PubMed. Differentially expressed autoantibodies were determined between patients and historial healthy controls, and related factors were identified by multivariate logistic regression analysis.

Results

In a total of 557 patients, 113 cases were detected with 19 kinds of positive autoantibodies, among them anti-?2-glycoprotein I (?2-GPI) antibody was most frequent (9.16%). Compared with historial healthy controls, the frequencies of serum ?2-GPI and anti SS-B antibody in patients were significantly higher, while frequencies of anti-smooth muscle antibody and anticardiolipin antibody were significantly lower (all P?ConclusionsFour autoantibodies were expressed differentially between patients with non-AIP CP and historial healthy controls. Due to limited significance for diagnosis and treatment of chronic pancreatitis, autoantibodies detection is not recommended conventionally unless suspected of AIP.

SUBMITTER: Zeng XP

PROVIDER: S-EPMC6376735 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Autoantibody detection is not recommended for chronic pancreatitis: a cross-sectional Study of 557 patients.

Zeng Xiang-Peng XP Liu Ting-Ting TT Hao Lu L Xin Lei L Wang Teng T He Lin L Pan Jun J Wang Dan D Bi Ya-Wei YW Ji Jun-Tao JT Liao Zhuan Z Du Ting-Ting TT Lin Jin-Huan JH Zhang Di D Guo Hong-Lei HL Chen Hui H Zou Wen-Bin WB Li Bai-Rong BR Cong Zhi-Jie ZJ Wang Li-Sheng LS Xu Zheng-Lei ZL Xie Ting T Liu Ming-Hao MH Deng An-Mei AM Li Zhao-Shen ZS Hu Liang-Hao LH

BMC gastroenterology 20190214 1

<h4>Background</h4>Autoimmune factor was regarded as one of the risk factors in the pathogenesis of chronic pancreatitis (CP), especially for autoimmune pancreatitis (AIP). However, whether autoimmune factor plays a role in non-AIP CP or not was unknown.<h4>Methods</h4>Hospitalized patients with non-AIP CP from January 2010 to October 2016 were detected for 22 autoantibodies at the time of hospital admission. Autoantibodies with frequency > 0.5% were enrolled to calculate the frequency in histor ...[more]

PMID: 30764766

Similar Datasets

Project description:BackgroundVaccine administration is a recommended, safe, and effective measure to protect pregnant women against vaccine-preventable diseases (VPDs). Despite available guidance, maternal immunization rates for vaccination against influenza and with the reduced antigen content tetanus-diphtheria-acellular pertussis vaccine (Tdap) in Italy remain incredibly low. The primary goal of the study was to explore what Italian pregnant women knew about VPDs and immunization during pregnancy and what factors affected their decision to be vaccinated.MethodsThis cross-sectional study took place between October 2021 and April 2022 in the Southern part of Italy. All consecutive pregnant women, from those attending the selected facilities on randomly selected days, were approached to request participation. The inclusion criteria for participation were age ≥18 years, the ability to understand, speak, and read Italian, and being pregnant at any gestational age. The questionnaire, using a combination of checkboxes and free text answers, consisted of 32 items divided into five parts and lasted ~10 min.ResultsThe results showed that 61% knew that the influenza vaccine is recommended and 48.7% knew that influenza could be risky during pregnancy; 74.1% wrongly reported that the Measles-Mumps-Rubella (MMR) vaccine is recommended during pregnancy. Seven out of 10 pregnant women believed that strong evidence supported the safety of vaccinations during pregnancy, and more than half (55.6%) thought they were at increased risk of severe illness with COVID-19. Women in the sample believed that vaccines received during pregnancy pose a risk of adverse events to the unborn child with a median value of 6 (IQR 3-9), on a scale ranging from 1 to 10. Similarly, the fear of contracting pertussis and influenza during pregnancy showed a median value of 6 (IQR 3-9) and 5 (IQR 3-8), respectively. Only 21.1% and 36.5% of women received influenza and Tdap vaccines during pregnancy.ConclusionUnrealistic risk perception with a negative attitude toward vaccines in pregnancy and a low percentage of vaccinated pregnant women confirm the urgency of training women to make informed choices to increase overall vaccine uptake.

Dataset Information

Autoantibody detection is not recommended for chronic pancreatitis: a cross-sectional Study of 557 patients.

Background

Methods

Results

Publications

Autoantibody detection is not recommended for chronic pancreatitis: a cross-sectional Study of 557 patients.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets