Ontology highlight
ABSTRACT:
SUBMITTER: Dohn TE
PROVIDER: S-EPMC6377147 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Dohn Tracy E TE Ravisankar Padmapriyadarshini P Tirera Fouley T FT Martin Kendall E KE Gafranek Jacob T JT Duong Tiffany B TB VanDyke Terri L TL Touvron Melissa M Barske Lindsey A LA Crump J Gage JG Waxman Joshua S JS
PLoS genetics 20190205 2
Multiple syndromes share congenital heart and craniofacial muscle defects, indicating there is an intimate relationship between the adjacent cardiac and pharyngeal muscle (PM) progenitor fields. However, mechanisms that direct antagonistic lineage decisions of the cardiac and PM progenitors within the anterior mesoderm of vertebrates are not understood. Here, we identify that retinoic acid (RA) signaling directly promotes the expression of the transcription factor Nr2f1a within the anterior late ...[more]