Ontology highlight
ABSTRACT:
SUBMITTER: Qin C
PROVIDER: S-EPMC6377448 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Qin Chong C Li Wei W Li Qin Q Yin Wen W Zhang Xiaowei X Zhang Zhiping Z Zhang Xian-En XE Cui Zongqiang Z
Proceedings of the National Academy of Sciences of the United States of America 20190109 7
Uncoating is an obligatory step in the virus life cycle that serves as an antiviral target. Unfortunately, it is challenging to study viral uncoating due to methodology limitations for detecting this transient and dynamic event. The uncoating of influenza A virus (IAV), which contains an unusual genome of eight segmented RNAs, is particularly poorly understood. Here, by encapsulating quantum dot (QD)-conjugated viral ribonucleoprotein complexes (vRNPs) within infectious IAV virions and applying ...[more]