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Sleep duration and apolipoprotein B in metabolically healthy and unhealthy overweight/obese phenotypes: a cross-sectional study in Chinese adults.


ABSTRACT:

Objectives

Short sleep duration is independently associated with an increased risk of developing cardiovascular disease; however, the association has not yet been examined in obese populations. We assessed the associations between sleep duration, metabolic phenotype and apolipoprotein variables in a nationally representative Chinese population with overweight/obesity.

Study design

Cross-sectional study.

Settings

The study conducted in nine provinces of China that vary substantially in geography and economic development.

Patients

Data were obtained from 4149 adults with overweight/obesity aged 18 to 94 years from the 2009 China Health and Nutrition Survey. Sleep duration was categorised as ?6, 7-8 or ?9?hour. Phenotypes were determined based on body mass index and metabolic health status and categorised as metabolically healthy overweight/obesity (MHOO) and metabolically unhealthy overweight/obesity (MUOO).

Main outcome measure

The outcome variables were elevated apolipoproteins.

Results

Compared with MHOO phenotype, MUOO phenotypes were more likely to report shorter sleep duration (12.2%vs9%). In the MUOO group, the multivariate-adjusted OR (95% CI) for elevated apolipoprotein B (apoB) was 1.66 (1.23 to 2.23) for those with ?6?hours of sleep and 1.12 (0.86 to 1.45) for those with ?9?hours of sleep, using 7-8?hours of sleep as a reference. Similar results were obtained in the subgroup of subjects who were ?45?or<45 years old, but shorter sleep duration was more strongly associated with elevated apoB in those <45 years (p interaction=0.023). However, no association was observed in the MHOO phenotype.

Conclusions

The high prevalence of short sleep duration and its strong association with elevated apoB in adults who are metabolically unhealthy overweight/obese suggest an increased risk of cardiovascular disease in this population. The differences in sleep sufficiency among obese phenotypes may account for the disparities in their cardiovascular outcomes.

SUBMITTER: Ren H 

PROVIDER: S-EPMC6377547 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Publications

Sleep duration and apolipoprotein B in metabolically healthy and unhealthy overweight/obese phenotypes: a cross-sectional study in Chinese adults.

Ren Huihui H   Zhang Lu L   Liu Zhelong Z   Zhou Xinrong X   Yuan Gang G  

BMJ open 20190211 2


<h4>Objectives</h4>Short sleep duration is independently associated with an increased risk of developing cardiovascular disease; however, the association has not yet been examined in obese populations. We assessed the associations between sleep duration, metabolic phenotype and apolipoprotein variables in a nationally representative Chinese population with overweight/obesity.<h4>Study design</h4>Cross-sectional study.<h4>Settings</h4>The study conducted in nine provinces of China that vary subst  ...[more]

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