Ontology highlight
ABSTRACT:
SUBMITTER: Zhang FP
PROVIDER: S-EPMC6377611 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Nature communications 20190215 1
Androgen receptor (AR) is regulated by SUMOylation at its transactivation domain. In vitro, the SUMOylation is linked to transcriptional repression and/or target gene-selective regulation. Here, we generated a mouse model (ArKI) in which the conserved SUMO acceptor lysines of AR are permanently abolished (Ar<sup>K381R, K500R</sup>). ArKI males develop normally, without apparent defects in their systemic androgen action in reproductive tissues. However, the ArKI males are infertile. Their spermat ...[more]