Ontology highlight
ABSTRACT:
SUBMITTER: Sugden K
PROVIDER: S-EPMC6377665 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Sugden Karen K Hannon Eilis J EJ Arseneault Louise L Belsky Daniel W DW Broadbent Jonathan M JM Corcoran David L DL Hancox Robert J RJ Houts Renate M RM Moffitt Terrie E TE Poulton Richie R Prinz Joseph A JA Thomson W Murray WM Williams Benjamin S BS Wong Chloe C Y CCY Mill Jonathan J Caspi Avshalom A
Translational psychiatry 20190215 1
Large-scale epigenome-wide association meta-analyses have identified multiple 'signatures'' of smoking. Drawing on these findings, we describe the construction of a polyepigenetic DNA methylation score that indexes smoking behavior and that can be utilized for multiple purposes in population health research. To validate the score, we use data from two birth cohort studies: The Dunedin Longitudinal Study, followed to age-38 years, and the Environmental Risk Study, followed to age-18 years. Longit ...[more]