Ontology highlight
ABSTRACT:
SUBMITTER: Zhou R
PROVIDER: S-EPMC6377835 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Zhou Ruobo R Yang Olivia O Déclais Anne-Cécile AC Jin Hyeonseok H Gwon Gwang Hyeon GH Freeman Alasdair D J ADJ Cho Yunje Y Lilley David M J DMJ Ha Taekjip T
Nature chemical biology 20190121 3
Holliday junction (HJ) resolution by resolving enzymes is essential for chromosome segregation and recombination-mediated DNA repair. HJs undergo two types of structural dynamics that determine the outcome of recombination: conformer exchange between two isoforms and branch migration. However, it is unknown how the preferred branch point and conformer are achieved between enzyme binding and HJ resolution given the extensive binding interactions seen in static crystal structures. Single-molecule ...[more]