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Blood Pressure Variability Is Associated with Hearing and Hearing Loss: A Population-Based Study in Males.

ABSTRACT: Blood pressure (BP) has been well documented to be associated with hearing loss previously. However, the role of blood pressure variability (BPV, representing BP fluctuation over a time period) on hearing remains unknown. We aimed to evaluate the relationship between BPV and hearing in Chinese population. We included 8646 male subjects from a population-based study (the Kailuan study). BP was measured every two years at routine physical examinations from 2006 to 2015. Based on five annual BP measurements, BPV was estimated by standard deviation of BP (SD), coefficient of the variation of BP (CV), and variation independent of mean of BP (VIM). Hearing was estimated by pure-tone average threshold (PTA) at low, intermediate, and high frequencies in the year of 2014. Regression models were used to evaluate the relationship between BPV and hearing. The results showed that PTAs and percentages of hearing loss at low, intermediate, and high frequencies grew gradually with increasing systolic SD (SSD) (p<0.05). After adjusting for multiple covariates, multivariate regression analyses demonstrated that variations of SBP (SSD, SCV, and VIM_SBP) were all positively correlated with PTA at intermediate and high frequencies (p<0.05). Each SD increase in SSD, SCV, and VIM_SBP was also positively associated with hearing loss at intermediate and high frequencies. No significant correlation was observed between variations of DBP and hearing. These findings suggest that increase in long-term BPV is associated with hearing and hearing loss. Trial registration number: Kailuan study (ChiCTRTNC-11001489).

SUBMITTER: Bao M

PROVIDER: S-EPMC6377956 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:ObjectiveWith data on frequency of hearing loss in Russia and Eastern Europe generally lacking, we assessed the prevalence of hearing loss in a Russian population.SettingThe population-based Ural Eye and Medical Study was conducted in the rural and urban regions of Bashkortostan, Russia.ParticipantsWith an inclusion criterion of age 40+ years, the study included 5899 (80.5%) out of 7328 eligible individuals (mean age: 59.0±10.7 years; range: 40-94 years).Primary and secondary outcome measuresHearing loss was examined in 5397 (91.5%) study participants, assessed using a standardised interview with questions from the 'Hearing Handicap Inventory for the Elderly Screening Version (HHIE-S)'.ResultsThe prevalence of self-reported hearing loss (26.1%, 95% CI 24.2 to 27.2) increased from 10.9% (95% CI 8.0 to 13.7) in participants aged 40-45 years old to 59.0% (95% CI 51.6 to 66.4) in those aged 80+ years old. It was higher for men than for women in the 60-80 years age group (38.93%, 95% CI 35.8 to 42.1, vs 32.8%, 95% CI 30.2 to 35.3; p=0.003). On multivariable analysis, higher prevalence of hearing loss was associated with older age (p<0.001; OR [per year of age]: 1.06 [1.06 to 1.07]), male gender (p<0.001; OR: 1.26 [1.09 to 1.47]), higher depression score (p<0.001; OR: 1.06 [1.04 to 1.08]), higher prevalence of headache (p=0.001; OR: 1.27 [1.10 to 1.47]), history of cardiovascular diseases including stroke (p=0.001; OR: 1.32 [1.13 to 1.55]), and osteoarthritis (p<0.001; OR: 1.40 [1.18 to 1.67]), physically vigorous activity during work (p<0.001; OR: 1.40 [1.21 to 1.62]), alcohol consumption (p<0.001; OR: 1.51 [1.28 to 1.78]), and dry eye feeling (p<0.001; OR: 1.67 [1.30 to 2.16]). It was marginally correlated with a higher anxiety score (p=0.07; OR: 1.03 [0.998 to 1.06]). It was independent of diabetes (p=0.52), arterial hypertension (p=0.20), level of education (p=0.11), region of habitation (p=0.70), blood concentration of high-density lipoproteins (p=0.17) and low-density lipoproteins (p=0.52), current smoking (p=0.95) and smoking pack-years (p=0.37), and best corrected visual acuity (p=0.93).ConclusionsAs in other countries the prevalence of hearing loss is high in this elderly population in Russia. It is primarily or secondarily associated with older age, depression, male gender, cardiovascular disease and alcohol consumption.

Project description:Background & aimsSensorineural hearing loss (HL) is one of the most common public health problems, and its prevalence increases with increasing life expectancy. An association between HL and metabolic syndrome (MetS) is suspected. Although previous epidemiological studies have investigated the association between the two variables, there have been conflicting conclusions. Therefore, we aimed to evaluate the association between the presence of MetS-and individual components of MetS-and HL, using a longitudinal design and a large-scale population.MethodsA total of 17,513,555 individuals who underwent national health screening between January 2009 and December 2010 were identified. Subject data from the Korean Health Insurance Review and Assessment Service were reviewed. A total of 11,457,931 subjects were ultimately included in the analysis. Baseline comorbidities were defined according to the ICD-10 code from the Korean Health Insurance Review and Assessment Service data. If the participants had an ICD-10 code for HL during the follow-up, they were defined as having incident HL. Criteria for MetS adhered to the revised National Cholesterol Education Program Adult Treatment Panel III.ResultsThere were 7,574,432 subjects without MetS and 3,883,499 with MetS. The incidence of HL in subjects without MetS and with MetS was 1.3% and 1.8% at 1 year, 4.1% and 5.2% at 3 years, and 6.8% and 8.6% at 5 years, respectively (P < 0.001). However, multivariate analyses revealed a negative association. Analyses according to the components of MetS demonstrated a positive association for those associated with dyslipidemia; however, the others exhibited an inverse association with HL. We also performed analyses using 4 groups according to the presence of MetS and the components of dyslipidemia. Univariate analysis revealed a positive association between the presence of MetS and HL; however, multivariate analysis revealed a positive association between the presence of dyslipidemia components and HL, regardless of the presence of MetS.ConclusionAmong the components of MetS, the association between low HDL or high TG levels and HL was most apparent. It is useful to evaluate each MetS component in isolation, such as the presence of low HDL or high TG levels, rather than the presence of MetS as a cluster of components.

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Blood Pressure Variability Is Associated with Hearing and Hearing Loss: A Population-Based Study in Males.

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