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Recurrent Acute Abdomen as the Main Manifestation of Hereditary Angioedema.


ABSTRACT: A diagnosis of hereditary angioedema is usually made with recurrent episodes of swelling of the subcutaneous tissue with a family history. We herein report a case in which recurrent acute abdomen was the main manifestation of hereditary angioedema. A 45-year-old womon presented with a 10-year history of recurrent severe abdominal pain. Abdominal computed tomography revealed remarkable submucosal edema of the ileum. A blood examination revealed grossly reduced complement C4 and CH50 with deficiency of C1-inhibitor. Genetic testing revealed a heterozygous nonsense mutation of the SERPING1 gene, and a diagnosis of hereditary angioedema was made. Hereditary angioedema should be listed as a differential diagnosis of recurrent acute abdomen.

SUBMITTER: Iwanami K 

PROVIDER: S-EPMC6378167 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Recurrent Acute Abdomen as the Main Manifestation of Hereditary Angioedema.

Iwanami Keiichi K   Okano Tsubasa T   Ohara Osamu O   Morio Tomohiro T  

Internal medicine (Tokyo, Japan) 20180824 2


A diagnosis of hereditary angioedema is usually made with recurrent episodes of swelling of the subcutaneous tissue with a family history. We herein report a case in which recurrent acute abdomen was the main manifestation of hereditary angioedema. A 45-year-old womon presented with a 10-year history of recurrent severe abdominal pain. Abdominal computed tomography revealed remarkable submucosal edema of the ileum. A blood examination revealed grossly reduced complement C4 and CH50 with deficien  ...[more]

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