Ontology highlight
ABSTRACT:
SUBMITTER: Zhuang C
PROVIDER: S-EPMC6378205 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Zhuang Changshui C Zhuang Chengle C Luo Xiaomin X Huang Xinbo X Yao Lv L Li Jianfa J Li Yawen Y Xiong Tiefu T Ye Jing J Zhang Fangting F Gui Yaoting Y
Journal of cellular and molecular medicine 20190116 3
The abundant and reversible N6-methyladenosine (m6A) RNA modification and its modulators have important roles in regulating various gene expression and biological processes. Here, we demonstrate that fat mass and obesity associated (FTO), as an m6A demethylase, plays a critical anti-tumorigenic role in clear cell renal cell carcinoma (ccRCC). FTO is suppressed in ccRCC tissue. The low expression of FTO in human ccRCC correlates with increased tumour severity and poor patient survival. The Von Hi ...[more]