Ontology highlight
ABSTRACT:
SUBMITTER: Makino CL
PROVIDER: S-EPMC6378327 | biostudies-literature | 2019 Jan-Feb
REPOSITORIES: biostudies-literature
Makino Clint L CL Duda Teresa T Pertzev Alexandre A Isayama Tomoki T Geva Polina P Sandberg Michael A MA Sharma Rameshwar K RK
eNeuro 20190101 1
The membrane guanylate cyclase, ROS-GC, that synthesizes cyclic GMP for use as a second messenger for visual transduction in retinal rods and cones, is stimulated by bicarbonate. Bicarbonate acts directly on ROS-GC1, because it enhanced the enzymatic activity of a purified, recombinant fragment of bovine ROS-GC1 consisting solely of the core catalytic domain. Moreover, recombinant ROS-GC1 proved to be a true sensor of bicarbonate, rather than a sensor for CO<sub>2</sub>. Access to bicarbonate di ...[more]