Ontology highlight
ABSTRACT:
SUBMITTER: Wilson TA
PROVIDER: S-EPMC6378678 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20190130 2
Allosteric HIV-1 integrase inhibitors (ALLINIs) are a new class of potential antiretroviral therapies with a unique mechanism of action and drug resistance profile. To further extend this class of inhibitors via a scaffold hopping approach, we have synthesized a series of analogues possessing an isoquinoline ring system. Lead compound <b>6l</b> binds in the v-shaped pocket at the IN dimer interface and is highly selective for promoting higher-order multimerization of inactive IN over inhibiting ...[more]