Ontology highlight
ABSTRACT:
SUBMITTER: Zhou R
PROVIDER: S-EPMC6379068 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Zhou Rongying R Wang Gaofeng G Kim Dongwon D Kim Sooah S Islam Nasif N Chen Ruosi R Wang Zixiao Z Li Ang A McCarthy Edward F EF Li Li L Hu Zhiqi Z Garza Luis A LA
The Journal of investigative dermatology 20180816 1
How cell and tissue identity persist despite constant cell turnover is an important biologic question with cell therapy implications. Although many mechanisms exist, we investigated the controls for site-specific gene expression in skin, given its diverse structures and functions. For example, the transcriptome of in vivo palmoplantar (i.e., volar) epidermis is globally unique, including Keratin 9 (KRT9). Although volar fibroblasts have the capacity to induce KRT9 in nonvolar keratinocytes, we s ...[more]