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Salivary uric acid: Associations with resting and reactive blood pressure response to social evaluative stress in healthy African Americans.


ABSTRACT: High levels of uric acid are associated with greater risk of stress-related cardiovascular illnesses that occur disproportionately among African Americans. Whether hyperuricemia affects biological response to acute stress remains largely unknown, suggesting a need to clarify this potential connection. The current study examined how salivary uric acid (sUA) is associated with resting and reactive blood pressure - two robust predictors of hypertension and related cardiovascular disease and disparity. Healthy African Americans (N?=?107; 32% male; M age?=?31.74 years), completed the Trier Social Stress Test to induce social-evaluative stress. Systolic and diastolic blood pressure readings were recorded before, during, and after the task to assess resting and reactive change in blood pressure. Participants also provided a saliva sample at baseline that was assayed for sUA. At rest, and controlling for age, sUA was modestly associated with higher systolic (r?=?.201, p?=? .044), but not diastolic (r?=?.100, p?=? .319) blood pressure. In response to the stressor task, and once again controlling for age, sUA was also associated with higher total activation of both systolic (r?=?.219, p?=? .025) and diastolic blood pressure (r?=?.198, p?

SUBMITTER: Woerner J 

PROVIDER: S-EPMC6379116 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Salivary uric acid: Associations with resting and reactive blood pressure response to social evaluative stress in healthy African Americans.

Woerner Jacqueline J   Lucas Todd T   Pierce Jennifer J   Riis Jenna L JL   Granger Douglas A DA  

Psychoneuroendocrinology 20181026


High levels of uric acid are associated with greater risk of stress-related cardiovascular illnesses that occur disproportionately among African Americans. Whether hyperuricemia affects biological response to acute stress remains largely unknown, suggesting a need to clarify this potential connection. The current study examined how salivary uric acid (sUA) is associated with resting and reactive blood pressure - two robust predictors of hypertension and related cardiovascular disease and dispari  ...[more]

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