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ABSTRACT: Background/aims
While substantial prior research has evaluated the psychometric properties of the 12-item Concise Health Risk Tracking-Self Report (CHRT-SR12), a measure of suicide propensity and suicidal thoughts, no prior research has investigated its factor structure, sensitivity to change over time, and other psychometric properties in a placebo-controlled trial of antidepressant medication, nor determined whether symptoms change throughout treatment.Methods
Participants in the multi-site Establishing Moderators and Biosignatures of Antidepressant Response in Clinical Care (EMBARC) study ( n=278) provided data to evaluate the factor structure and sensitivity to change over time of the CHRT-SR12 through eight weeks of a clinical trial in which participants received either placebo or antidepressant medication (sertraline).Results/outcomes
Factor analysis confirmed two factors: propensity (comprised of first-order factors including pessimism, helplessness, social support, and despair) and suicidal thoughts. Internal consistency (α's ranged from 0.69-0.92) and external validity were both acceptable, with the total score and propensity factor scores significantly correlated with total scores and single-item suicidal-thoughts scores on the self-report Quick Inventory of Depressive Symptoms and the clinician-rated 17-item Hamilton Rating Scale for Depression. Through analyzing CHRT-SR12 changes over eight treatment weeks, the total score and both the factors decreased regardless of baseline suicidal thoughts. Change in clinician-rated suicidal thoughts was reflected by change in both the total score and propensity factor score.Conclusions/interpretation
These results confirm the reliability, validity, and applicability of the CHRT-SR12 to a placebo-controlled clinical trial of depressed outpatients receiving antidepressant medication.
SUBMITTER: Trombello JM
PROVIDER: S-EPMC6379122 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Trombello Joseph M JM Killian Michael O MO Grannemann Bruce D BD Rush Augustus John AJ Mayes Taryn L TL Parsey Ramin V RV McInnis Melvin M Jha Manish K MK Ali Aasia A McGrath Patrick J PJ Adams Phil P Oquendo Maria A MA Weissman Myrna M MM Carmody Thomas J TJ Trivedi Madhukar H MH
Journal of psychopharmacology (Oxford, England) 20190117 2
<h4>Background/aims</h4>While substantial prior research has evaluated the psychometric properties of the 12-item Concise Health Risk Tracking-Self Report (CHRT-SR<sub>12</sub>), a measure of suicide propensity and suicidal thoughts, no prior research has investigated its factor structure, sensitivity to change over time, and other psychometric properties in a placebo-controlled trial of antidepressant medication, nor determined whether symptoms change throughout treatment.<h4>Methods</h4>Partic ...[more]