Ontology highlight
ABSTRACT:
SUBMITTER: Paganoni S
PROVIDER: S-EPMC6379136 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Muscle & nerve 20181226 3
<h4>Introduction</h4>RNS60 is a novel immune-modulatory agent that has shown neuroprotective effects in amytrophic lateral sclerosis (ALS) preclinical models. RNS60 is administered by weekly intravenous infusion and daily nebulization. The objective of this pilot open-label trial was to test the feasibility, safety, and tolerability of long-term RNS60 administration in ALS patients.<h4>Methods</h4>The planned treatment duration was 23 weeks and the primary outcomes were safety and tolerability. ...[more]