Ontology highlight
ABSTRACT:
SUBMITTER: van der Touw W
PROVIDER: S-EPMC6379207 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
van der Touw William W Kang Kyeongah K Luan Yi Y Ma Ge G Mai Sunny S Qin Lihui L Bian Guanglin G Zhang Ruihua R Mungamuri Sathish Kumar SK Hu Hong-Ming HM Zhang Cheng Cheng CC Aaronson Stuart A SA Feldmann Marc M Yang Wen-Chin WC Chen Shu-Hsia SH Pan Ping-Ying PY
Journal of immunology (Baltimore, Md. : 1950) 20180801 6
Glatiramer acetate (GA; Copaxone) is a copolymer therapeutic that is approved by the Food and Drug Administration for the relapsing-remitting form of multiple sclerosis. Despite an unclear mechanism of action, studies have shown that GA promotes protective Th2 immunity and stimulates release of cytokines that suppress autoimmunity. In this study, we demonstrate that GA interacts with murine paired Ig-like receptor B (PIR-B) on myeloid-derived suppressor cells and suppresses the STAT1/NF-κB pathw ...[more]